Interdisciplinary investigation of cellular division machinery
We use budding yeast to investigate the assembly and function of the mitotic spindle, and the control systems that govern asymmetric cell division.
Understanding spindle assembly and positioning through mutant analysis, high throughput genetic screening, protein-protein interaction assays, experimental evolution.
Applying modern computational methods to process and model complex biological data for hypothesis generation.
Elucidating the dynamics and forces that govern microtubule spindle assembly and function combining physical models and in-vivo fluorescence microscopy.
The lab is always interested in creative and motivated students and postdoctoral fellows to work in our collaborative interdisciplinary group.
The Vogel group is recruiting post-doctoral researchers for January, 2018. The successful applicant will join a inter-disciplinary research group focused on applying biophysical and computational methods to the study of spindle assembly.
Position 1: Biochemist, with a background in protein biochemistry, molecular biology and in vitro assays.
Project: Structure-function analysis of γ-tubulin and the γ-TuC, phosphoregulation of γ-tubulin
The applicant should have an interest in cell biology, biophysics and structural biology. Experience with microscopy, molecular biology methods, protein expression and purification, experience with Sf9 cell expression is particularly desirable.
Position 2: Cell and molecular biologist, background in biological or physical sciences.
Project: Control of spindle assembly and positioning during asymmetric cell division.
The applicant should have an interest in cell biology, biophysics and structural biology. Experience with microscopy, molecular biology and molecular genetics. Experience with MatLab/Python/FIJI scripting is desirable.
Undergraduate research opportunities for summer 2018
Typically two positions are available each summer. Undergraduate students interested in experimental biophysics research projects are encouraged to apply in January 2018.
Concerted millisecond timescale dynamics in the intrinsically disordered carboxyl terminus of ɣ-tubulin induced by mutation of a conserved tyrosine residue.
Jason Harris*, Maria Shadrina*, Carlos Oliver, Jackie Vogel^ and Anthony Mittermaier^ Concerted millisecond timescale dynamics in the intrinsically disordered carboxyl terminus of ɣ-tubulin induced by mutation of a conserved tyrosine residue. Protein Science (2017). *equal contribution. ^corresponding authors.
Spatial cues and not spindle pole maturation drive the asymmetry of astral microtubules between new and pre-existing spindle poles
Jette Lengefeld*, Eric Yen*, Xiuzhen Chen, Allen Leary, Jackie Vogel^ and Yves Barral1^ Spatial cues and not spindle pole maturation drive the asymmetry of astral microtubules between new and pre-existing spindle poles. MBoC (2017). *equal contribution. ^corresponding authors.
Interrogation of ɣ-tubulin alleles using high-resolution fitness measurements
K Shulist*, E Yen*, S Kaitna, A Leary, A Decterov, D Gupta and J Vogel. Interrogation of ɣ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment Scientific Reports 7:11398 (2017) *equal contribution
Jackie Vogel trained as a biochemist, focusing on mechanisms of centrosome maturation (Ph.D. University of Kansas, Ida Hyde and Candlin Scholar). Jackie studied the role of gamma-tubulin regulation in cell division at Yale University as a NIH and Leslie Warner post doctoral fellow (1996 - 2001). At McGill, Jackie has been a CIHR New Investigator (2004-2009) and most recently held the McGill-Canadian Pacific Biotechnology research chair (2009-2014). She is currently leading the Quantitative Biology Initiative at McGill, acting as the coordinator of the Quantitative Biology honours and majors options in the Department of Biology, and the CS - Biology joint B.Sc. program.
Jackie’s research program is supported by NSERC, CIHR and the CFI.
PD Research Associate
Administrator, Integrated Quantitative Biology Initiative Genetic screens for elucidating the regulation of gamma-Tubulin interaction network.
Ph.D. Institute of Molecular Pathology
PD Research Associate
Computational chemistry/biology; protein structure-function analysis in silico
Kar9 mediated spindle alignmnent
PhD in Molecular and Cellular Biology at Claude Bernard University of Lyon (UCBL)
biochemistry; structure-function analysis of gamma-tubulin complexes
Ph.D in Microbiology/Chemistry University Claude Bernard (Lyon- France)
Investigating the biological significance of multi-site phosphorylation in gamma-tubulin.
B.Sc. Honours Biology
Supported by an NSERC fellowship.
Applying physics and modeling techniques of biological systems.
B.Sc. , M.Sc. Physics
(McGill University and TRIUMF)
Supported by a fellowship from the CDMC CREATE program and a Trottier science accelerator fellowship.
Biophysics; spindle forces and symmetry breaking
B.Sc. Physics McGill University