About us

We use budding yeast to investigate the assembly and function of the mitotic spindle,
and the control systems that govern asymmetric cell division.

Biological

Understanding spindle assembly through mutant analysis, high throughput genetic screening, protein-protein interaction assays, experimental evolution.

Computational

Applying modern computational methods to process and model complex biological data for hypothesis generation.

Physical

Elucidating the dynamics and forces that govern microtubule spindle assembly and function combining physical models and in-vivo fluorescence microscopy.

Recent Publications

Dynamic properties of protein complexes

Eric Yen, Aaron Tsay, Jerome Waldispuhl, Jackie Vogel*. Exploration of the dynamic properties of protein complexes predicted from spatially constrained protein-protein interaction networks. PLoS Computational Biology (2014).

Microtubule pairing in spindle assembly

Nazarova E, O'Toole E, Kaitna S, Francois P, Winey M, Vogel J. Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly. Molecular Biology of the Cell (2013).

People

Jackie Vogel

Group Leader
Associate Professor of Biology

Jackie Vogel trained as a biochemist, focusing on mechanisms of centrosome maturation (Ph.D. University of Kansas, Ida Hyde and Candlin Scholar). Jackie studied the role of gamma-tubulin regulation in cell division at Yale University as a NIH and Leslie Warner post doctoral fellow (1996 - 2001). At McGill, Jackie has been a CIHR New Investigator (2004-2009) and most recently held the McGill-Canadian Pacific Biotechnology research chair (2009-2014). She is currently leading the Quantitative Biology Initiative at McGill, acting as the coordinator of the Quantitative Biology honours and majors options in the Department of Biology, and the CS - Biology joint B.Sc. program.

Jackie’s research program is supported by NSERC, CIHR and the CFI.

Susi Kaitna

PD Research Associate
Genetic screens for elucidating the regulation of gamma-Tubulin interaction network.

Ph.D. Institute of Molecular Pathology
(Vienna, Austria)




Eric Yen

Ph.D. Candidate
Developing new tools to investigate the structure-function relationships within protein complexes.

B.Sc. Quantitative Biology
(McGill University)

Supported by a fellowship from the CDMC CREATE program.

Kristy Shulist

Ph.D. Candidate
Investigating the biological significance of multi-site phosphorylation in gamma-tubulin.

B.Sc. Honours Biology
(McMaster University)

Supported by an NSERC fellowship.


Allen Leary

Ph.D. Student
Applying physics and modelling techniques of biological systems.


B.Sc. , M.Sc. Physics
(McGill University and TRIUMF)

Supported by a fellowship from the CDMC CREATE program and a Trottier science accelerator fellowship.

Carlos Oliver

M.Sc. Student
Developing computational and experimental tools to study the evolution of molecular systems.

B.Sc. Computer Science and Biology (McGill University)

Supported by a fellowship from the CDMC CREATE program.


Youssef Hsheimi

Research Assistant
Symmetry breaking of the mitotic spindle.



B.Sc. Honours Biology
(McGill University)



Positions

New positions are available for undergraduates and post doctoral fellows. Please contact Jackie Vogel for more information.

Publications